Serum transferrin receptor is a truncated form of tissue receptor.

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Serum transferrin receptor is a truncated form of tissue receptor.

Recent studies have provided immunological evidence for the existence of transferrin receptor in human serum and have revealed that its concentration is a sensitive measure of erythropoiesis and iron deficiency. The present study was undertaken to establish the molecular identity of this immunoreactive component. Purification from human serum was accomplished by immunoaffinity chromatography us...

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Origin of a soluble truncated transferrin receptor.

It has recently become evident that elevation of reticulocytes in the circulation of several species, including humans, leads to the formation of a noncellular transferrin receptor (TFR). In humans, the majority of the released receptor is in truncated form (Shih et al: J Biol Chem 265:19077, 1990). In other species (sheep, rat, chicken) the receptor is associated with a vesicle (exosome) and i...

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Serum transferrin receptor: a quantitative measure of tissue iron deficiency.

This study was undertaken to evaluate the role of serum transferrin receptor measurements in the assessment of iron status. Repeated phlebotomies were performed in 14 normal volunteer subjects to obtain varying degrees of iron deficiency. Serial measurements of serum iron, total iron-binding capacity, mean cell volume (MCV), free erythrocyte protoporphyrin (FEP), red cell mean index, serum ferr...

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Serum transferrin receptor in polycythemia

anti-HGV antibodies directed against the E2 structural protein (immunoenzymatic method), a reliable serologic marker of past HGV infection followed by viral clearance.8 Serum specimens were taken at the onset of the disease and stored at –20°C; we found only one patient with HGV positivity by RT-PCR (3%). Twenty-six of 33 patients were positive for anti HGV/E2 antibodies (78.8%) suggesting past...

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Serum soluble transferrin receptor concentration is an accurate estimate of the mass of tissue receptors.

OBJECTIVE Serum levels of the soluble transferrin receptor (sTfR) vary depending on the erythropoietic activity and iron status. In vitro, sTfR shed in the incubation medium correlates well with cellular TfR, but this relationship has never been established in vivo. To determine the value of serum sTfR as a quantitative marker of the body mass of tissue TfR, we designed experiments to examine t...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1990

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(17)30627-0